TCO reagents - NEW RANGE OF PRODUCTS

Primetech now offers TCO reagents:
 

TCO TEG Phosphoramidite is a specialized reagent designed for the site-specific incorporation of a trans-cyclooctene (TCO) moiety into oligonucleotides during solid-phase synthesis. It features a strained TCO alkene linked via a tetra(ethylene glycol) spacer to a phosphoramidite group, allowing for efficient 5'-end modification of DNA or RNA strands. The TEG linker provides flexibility and hydrophilicity, minimizing steric hindrance and enhancing solubility in aqueous environments. 

TCO OH , formally known as (E)-cyclooct-4-enol, is a strained trans-cyclooctene derivative featuring a terminal hydroxyl group. This compound is widely used in bioorthogonal chemistry, particularly in click reactions with tetrazines, due to its rapid kinetics and high selectivity.

TCO NHS, also known as trans-cyclooctene-N-hydroxysuccinimidyl carbonate, is a highly reactive amine-targeting reagent used in bioorthogonal chemistry. It features a strained trans-cyclooctene (TCO) moiety linked to an NHS carbonate group, enabling efficient conjugation to primary amines on biomolecules such as proteins, peptides, or small molecules.

TCO PEG4 NHS succinate is a highly reactive amine-targeting reagent used in bioorthogonal chemistry. It features a strained trans-cyclooctene (TCO) moiety linked to an NHS carbonate group via tetra(ethylene glycol) spacer, enabling efficient conjugation to primary amines on biomolecules such as proteins, peptides, or small molecules.

TCO TEG NHS carbonate is a highly reactive amine-targeting reagent used in bioorthogonal chemistry. It features a strained trans-cyclooctene (TCO) moiety linked to an NHS carbonate group via tetra(ethylene glycol) spacer, enabling efficient conjugation to primary amines on biomolecules such as proteins, peptides, or small molecules.