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Primetech Announces New Scientific Advisory Board Member

      Primetech is pleased to have Dr Mikhail Shchepinov join our Scientific Advisory Board.
      Mikhail completed his PhD in Moscow in 1994 in the field of bioorganic chemistry, focusing on various ways of chemically splitting  synthetic oligonucleotides. He was then at Oxford University developing chemical tools for solid phase-based DNA devices (oligonucleotide arrays, DNA chips), working at the interface of solid phase, combinatorial, dendrimer and fluorophore chemistries. Later in the biotech industry (San Diego, Oxford),  Mikhail has expanded his areas of interest to cover chemical genomics and proteomics and isotope labeling. Several of the reagents he developed are now commercially available.
      Mikhail has published on these topics, and has about 90 patents. 

               Main publications:

  1. Shchepinov, M. S., & Southern, E. M. (1998). The synthesis of branched oligonucleotide structures. Биоорганическая химия, 24(10), 794-797.
  2. Shchepinov, M. S., Mir, K. U., Elder, J. K., Frank-Kamenetskii, M. D., & Southern, E. M. (1999). Oligonucleotide dendrimers: stable nano-structures. Nucleic Acids Research, 27(15), 3035-3041.
  3. Southern, E., Mir, K., & Shchepinov, M. (1999). Molecular interactions on microarrays. Nature genetics, 21(1), 5-9.
  4. Shchepinov, M. S., Korshun, V. A., Egeland, R. D., & Southern, E. M. (2000). Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels. Tetrahedron Letters, 41(25), 4943-4948.
  5. Birikh, K. R., Bernad, P. L., Shmanai, V. V., Malakhov, A. D., Shchepinov, M. S., & Korshun, V. A. (2009). SNP detection using trityl mass tags. Single Nucleotide Polymorphisms: Methods and Protocols, 345-361.
  6. Shchepinov, M. S., Chalk, R., & Southern, E. M. (1999, November). Trityl mass-tags for encoding in combinatorial oligonucleotide synthesis. In Nucleic acids symposium series (Vol. 42, No. 1, pp. 107-108). Oxford University Press.
  7. Bernad Jr, P. L., Khan, S., Korshun, V. A., Southern, E. M., & Shchepinov, M. S. (2005). S (O)-Pixyl protecting group as efficient mass-tag. Chemical Communications, (27), 3466-3468.
  8. Shchepinov, M. S., & Korshun, V. A. (2003). Recent applications of bifunctional trityl groups. Chemical Society Reviews, 32(3), 170-180.
  9. Khan, S., Bernad, P. L., Korshun, V. A., Southern, E. M., & Shchepinov, M. S. (2005). Synthesis of S-pixyl derivatives for mass spectrometric applications. Synlett, 2005(16), 2453-2456.
  10. Shchepinov, M. S., & Stetsenko, D. A. (1997). A facile route to 3′-modified oligonucleotides. Bioorganic & Medicinal Chemistry Letters, 7(9), 1181-1184.
  11. Shchepinov, M. S., & Korshun, V. A. (2001). Design of multidye systems for FRET-based applications. Nucleosides, Nucleotides and Nucleic Acids, 20(4-7), 369-374.
  12. Shchepinov, M. S., Chalk, R., & Southern, E. M. (2000). Trityl tags for encoding in combinatorial synthesis. Tetrahedron, 56(17), 2713-2724.
  13. Shchepinov, M. S., Denissenko, M. F., Smylie, K. J., Wörl, R. J., Leppin, A. L., Cantor, C. R., & Rodi, C. P. (2001). Matrix-induced fragmentation of P3′-N5′ phosphoramidate-containing DNA: high-throughput MALDI-TOF analysis of genomic sequence polymorphisms. Nucleic acids research, 29(18), 3864-3872.
  14. Thiery, G., Shchepinov, M. S., Southern, E. M., Audebourg, A., Audard, V., Terris, B., & Gut, I. G. (2007). Multiplex target protein imaging in tissue sections by mass spectrometry–TAMSIM. Rapid Communications in Mass Spectrometry: An International Journal Devoted to the Rapid Dissemination of Up‐to‐the‐Minute Research in Mass Spectrometry, 21(6), 823-829.
  15. Hussain, M., Shchepinov, M., Sohail, M., Benter, I. F., Hollins, A. J., Southern, E. M., & Akhtar, S. (2004). A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. Journal of Controlled Release, 99(1), 139-155.

 

 

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