Cholesterol phosphoramidite

Cholesterol phosphoramidite

Cat. number: 1125
Availability:
In Stock
Price: 80 €

Available Options


Description

Molecular Formula

C69H101N4O8P

Molecular Weight

1145.6 g/mol

Chemical Name

(1S,2R,5S,10S,11S,14R,15R)-2,15‐dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.02,7.011,15]heptadec‐7‐en‐5‐yl N‐{6‐[(2S,4R)‐2‐{[bis(4‐methoxyphenyl)(phenyl)methoxy]methyl}‐4‐({[bis(propan‐2‐yl)amino](2‐cyanoethoxy)phosphanyl}oxy)pyrrolidin‐1‐yl]‐6‐oxohexyl}carbamate

Appearance

White foam

Assay

≥99% (NMR)

Storage Conditions

Keep in a dark and dry place at -20°C

Shelf Life

1 year

Usage

Dilution: dilute 100 mg of Cholesterol phosphoramidite Pro in
0.87 mL of 10% THF in anhydrous acetonitrile to obtain 0.1M solution. Swirl occasionally over several minutes until product is completely dissolved

Oxidation: standard iodine solution

Coupling: 15 minute coupling time

Deprotection: cleave and deprotect as required by nucleobases

1H NMR (CD3CN)

Conforms to the internal standard

31P NMR (CD3CN)

Conforms to the internal standard