Imidazole-1-sulfonyl azide is a crystalline, shelf-stable reagent for the preparation of azides from amines, e. g. aminosugars, aminoacids, and anilines. Developed in 2007, imidazole-1-sulfonyl azide is a more safe substitute for the traditionally used diazo transfer reagents, such as trifluoromethanesulfonyl azide, tosyl azide and others (Org. Lett. 2007, 9, 19, 3797, doi: 10.1021/ol701581g).

We offer imidazole-1-sulfonyl azide in a form of recently discovered hydrogen sulfate salt which is even more stable than previously reported hydrocloride salt (J. Org. Chem. 2016, 81, 3443, doi: 10.1021/acs.joc.6b00177).

Imidazole-1-sulfonyl azide is especially useful for the click chemistry as it smoothly provides the needed azides and allows introduction of azide groups into biomolecules.